个人简介

2016年于中国药科大学博士毕业后，进入南京医科大学儿童医院重点实验室工作，于2017年评定为中级职称。本人一直致力于急慢性肾脏疾病的研究工作。近年在Science Translational Medicine（IF：16.304）、EBioMedicine （IF：6.68）等杂志发表SCI论文9篇（IF>50）。为SCI期刊Scientific Reports (IF:4.122)、PLoS ONE (IF:2.8)的审稿专家。近年主持国家自然科学基金等各类课题4项。2019年成为南京医科大学第一届青年编委会成员。

主持科研项目

1、 EVI-1/NM IIA/MG53通路在急性肾小管损伤中的作用研究（81700604），国家自然科学基金青年项目，2018-2020，20万。

2、NM IIA在急性肾小管损伤中的作用及机制研究（SBK2017041428），江苏省自然科学基金青年项目，2018-2020，20万

3、PXR在顺铂诱导的急性肾小管损伤中的作用及机制研究，中国博士后科学基金第63批面上资助项目，2018-2020，5万

4、NM IIA在急性肾小管损伤及修复中的作用及机制研究，南京医科大学科技发展基金重点项目，2017-2018，3万

代表性论文

1、 Yu xiaowen, Xu man, Meng xia, Li shumin, Liu qianqi, Bai mi, You ran, Huang songming, Yang li, Zhang yue*, Jia zhanjun*, Zhang aihua*, Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI. Science Translational Medicine. 2020 May 13;12(543).

2、Xu man#, Yu xiaowen#, Meng xia, Huang songming, Zhang yue, Zhang aihua, Jia zhanjun*, Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol. 2020, 318(3): 576-588.

3、Xiaowen Yu, Xia Meng, Man Xu, Xuejuan Zhang, Yue Zhang, Guixia Ding, Songming Huang, Aihua Zhang* and Zhanjun Jia*, Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function. EBioMedicine. 2018 Oct;36:266-280.

4、Yunwen Yang#, Xiaowen Yu#, Yue Zhang, Guixia Ding, Chunhua Zhu, Songming Huang, Zhanjun Jia* and Aihua Zhang*, Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) Protects against Cisplatin-induced Acute Kidney Injury. Clin Sci (Lond). 2018 Apr 16; 132(7):825-838.

5、Xiaowen Yu#, Dandan Wei #, Ying-Sheng Gao, Hong-Zhi Du, Bo-Yang Yu, Rui-Ming Li, Chang-Min Qian, Xue-Jun Luo, Sheng-Tao Yuan, Jun-Song Wang and Li Sun,Synergistic combination of DT-13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC-823 cells via NM IIA/EGFR/HK II axis. Journal of Cellular and Molecular Medicine. 2019 Oct;23(10):6622-6634.

6、Xiaowen Yu#, Yunwen Yang#, Hui Yuan, Meng Wu, Shuzhen Li, Wei Gong, Jing Yu, Weiwei Xia, Yue Zhang, Guixia Ding, Songming Huang, Zhanjun Jia* and Aihua Zhang*, Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis. American Journal of Translational Research. 2017 Mar 15;9(3):1222-1229.

7、 Xiaowen Yu, Qingqing Yang, Sensen Lin, Shengtao Yuan*, Li Sun*, Synergistic combination of YS-1 and Adriamycin inhibit human renal cancer through Erk1/2 signaling pathway in vitro and in vivo. Oncology Reports. 2017 Mar;37(3):1756-1764.

8、Xiaowen Yu, Sensen Lin, Hongzhi Du, Renping Zhao, Shuyun Feng, Boyang Yu, Luyong Zhang, Ruiming Li, Changmin Qian, Xuejun Luo, Shengtao Yuan*, Li Sun*, Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of egf receptor in vitro and in vivo. Oncotarget. 2016 May 31;7(22):32990-3003.

9、Xiaowen Yu#, Renping Zhao#, Sensen Lin, Xianshu Bai, Luyong Zhang, Li Sun*, Shengtao Yuan*, CXCL16 induces angiogenesis in autocrine signaling pathway involving hypoxia-inducible factor 1α in human umbilical vein endothelial cells. Oncology Reports. 2016 Mar; 35:1557-65.

10、Mengqiu Wu, Weiyi Chen, Xiaowen Yu, Dan Ding, Wen Zhang, Hu Hua, Man Xu, Xia Meng, Xuejuan Zhang, Yue Zhang, Aihua Zhang, Zhanjun Jia* and Songming Huang*, Celastrol aggravates LPS-induced inflammation and injuries of liver and kidney in mice. American Journal of Translational Research. 2018 Jul 15;10(7):2078-2086.

11、Mi Liu, Ying Sun, Man Xu, Xiaowen Yu, Yue Zhang, Songming Huang, Guixia Ding, Aihua Zhang and Zhanjun Jia*, Role of mitochondrial oxidative stress in modulating the expressions of aquaporins in obstructive kidney disease. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F658-F666.

12、Hongzhi Du, Yulong Chen, Xiaoying Hou, Yue Huang, Xiaohui Wei, Xiaowen Yu, Shuyun Feng, Yao Wu, Meixiao Zhan, Xin Shi, Sensen Lin, Ligong Lu, Shengtao Yuan*, Li Sun*, PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC. Cell Death and Disease. 2017 Oct 26; 8(10):e3143.

13、 Hongzhi Du, Yang Liu, Xudong Chen, Xiaowen Yu, Xiaoying Hou, Hongyang Li, Meixiao Zhan, Sensen Lin, Ligong Lu, Shengtao Yuan*, Li Sun*, DT-13 synergistically potentiates the sensitivity of gastric cancer cells to topotecan via cell cycle arrest in vitro and in vivo. European Journal of Pharmacology. 2017 Jan 5; 818:124-131.

14、Hongzhi Du, Yue Huang, Xiaoying Hou, Xiaowen Yu, Sensen Lin, Xiaohui Wei, Ruiming Li, Ghulam Jilany Khan, Shengtao Yuan*, Li Sun*, DT-13 inhibits cancer cell migration by regulating NMIIA indirectly in the tumor microenvironment. Oncology Reports. 2016 Aug;36(2):721-8.

申请专利

1、发明专利：PCN在制备用于治疗急性肾损伤相关病症的药物中的应用，发明人：张爱华，于晓文，贾占军，许曼，孟霞，张学娟，白咪，申请号：201810121267.4，实质审查阶段

2、发明专利：PCN在制备用于治疗慢性肾脏病相关病症的药物中的应用，申请号：201810121250.9，发明人：于晓文，张爱华，贾占军，白咪，孟霞，许曼，实质审查阶段

3、发明专利：PCN在制备用于治疗1型糖尿病肾病相关病症的药物中的应用，发明人：贾占军，于晓文，张爱华，许曼，孟霞，张学娟，公伟，李树珍，于婧，游，申请号：201810121259.X，实质审查阶段