主持科研项目或人才项目

1.      2018.01-2021.12 国家自然科学基金面上项目，LncRNA调控P2X7R/NLRP3信号通路介导CD4+T淋巴细胞亚群分化:幼年类风湿性关节炎发病新机制

2.      2018.01-2020.12 江苏省人社厅“六大人才高峰”B类，RP11-340F14.6通过调控P2X7R/NLRP3炎症小体信号通路介导关节炎CD4+T淋巴细胞亚群分化

3.      2022.01-2024.12 江苏省卫健委医学科研项-面上项目，LncRNA-SNHG5/miR-181/MEK信号通路介导幼年类风湿关节炎Th17/Treg细胞亚群失衡的机制研究

4.      2021.01-2024.12国家重点研发计划生育健康及妇女儿童健康保障专项-子课题，JIA早期诊断及精准分型评估体系的研究

5.      2023.01-2026.12国家自然科学基金面上项目  “XCR1+cDC1交叉抗原递呈—CD8+T细胞活化—骨稳态失衡”轴在附着点炎相关关节炎中的作用及机制研

代表性论文

1.      STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C Polymorphisms Influence the Risk of Developing Juvenile Idiopathic Arthritis in Han Chinese Patients, PLoS One.2015;10(3):e0117389.

2.      Involvement of P2X7 receptor signaling on  regulating the differentiation of  Th17 cells and type  II collagen-induced arthritis in mice, Scientific Reports . 2016;6:35804.

3.      Clinical Manifestations of Kawasaki Disease Shock Syndrome, Clinical Pediatrics. 2018;57(4):428-435.

4.      Platelet-derived microparticles: a new index of monitoring platelet activation and inflammation in kawasaki sisease, The Indian Journal of Pediatrics. 2019;86(3):250-255.

5.      Long non-coding RNA RP11-340F14;6 promotes a shift in the Th17/Treg ratio by binding with P2X7R in juvenile idiopathic arthritis, International Journal of Molecular Medicine. 2020;46:859-868.

6.      Clinical and laboratory features, treatment, and outcomes of macrophage activation syndrome in 80 children: a multi-center study in China; World Journal of Pediatrics.2020;16(1):89-98.

7.      Kikuchi-Fujimoto Disease with Encephalopathy in Children: Case Reports and Literature Review, Frontiers in Pediatrics. 2021;9:727411.

8.      Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis,Nature Communications.2021;12(6540):1-14.

获奖情况

1.      2018年江苏省妇幼保健新技术引进奖一等奖

2.      2020年江苏省卫生健康委医学引进新技术一等奖

3.      2021年南京市医学新技术一等奖